Biodistribution and radiation dosimetry of 124I-mIBG in adult patients with neural crest tumours and extrapolation to paediatric models

Moraitis, Alexandros; Jentzen, Walter; Reiter, Gloria; Schmitz, Jochen; Pöppel, Thorsten Dirk; Weber, Manuel; Herrmann, Ken; Fendler, Wolfgang Peter; Fragoso Costa, Pedro; Bockisch, Andreas; Kersting, David

doi:10.1186/s40658-023-00604-0

EJNMMI Physics

Table 4 Measured mean (± SD) organ absorbed dose coefficients (mGy/MBq) for ¹²⁴I-mIBG in adult patients and extrapolated values for reference paediatric patients pefined in ICRP89

From: Biodistribution and radiation dosimetry of ¹²⁴I-mIBG in adult patients with neural crest tumours and extrapolation to paediatric models

Organ	Organ absorbed dose (mGy/MBq)
Organ	Adult Male	Adult Female	15-yrs-old	10-yrs-old	5-yrs-old	1-yr-old	Newborn
Adrenals	0.297 (0.053)	0.314 (0.075)	0.361	0.560	0.883	1.64	3.44
Brain	0.134 (0.026)	0.137 (0.045)	0.155	0.248	0.392	0.684	1.57
Breast		0.141 (0.042)	0.148
Esophagus	0.202 (0.033)	0.218 (0.050)	0.251	0.400	0.651	1.24	3.03
Eyes	0.132 (0.025)	0.137 (0.045)	0.154	0.245	0.404	0.705	1.61
Gallbladder wall	0.329 (0.064)	0.259 (0.065)	0.328	0.496	0.770	1.39	3.39
Left colon	0.201 (0.032)	0.263 (0.133)	0.226	0.361	0.570	0.974	2.37
Right colon	0.220 (0.033)	0.210 (0.059)	0.243	0.375	0.581	0.998	2.39
Small intestine	0.214 (0.032)	0.202 (0.054)	0.249	0.386	0.593	1.04	2.37
Stomach wall	0.210 (0.032)	0.209 (0.055)	0.239	0.352	0.560	0.960	2.31
Rectum	0.254 (0.029)	0.320 (0.080)	0.351	0.545	0.831	1.33	3.12
Heart wall	0.513 (0.200)	0.649 (0.105)	0.677	1.26	1.75	2.59	8.27
Kidneys	0.347 (0.088)	0.355 (0.080)	0.412	0.649	1.04	1.85	4.49
Liver	0.608 (0.179)	0.689 (0.260)	0.755	1.19	1.89	3.34	8.27
Lungs	0.186 (0.029)	0.200 (0.052)	0.224	0.336	0.525	0.942	2.26
Ovaries/Prostate	0.289 (0.036)	0.240 (0.064)	0.311	0.633	0.749	1.23	2.71
Pancreas	0.230 (0.034)	0.264 (0.063)	0.285	0.434	0.676	1.21	2.83
Salivary glands	0.704 (0.237)	0.829 (0.325)	0.918	1.48	2.42	4.41	10.8
Red marrow	0.175 (0.025)	0.174 (0.044)	0.195	0.262	0.372	0.654	1.24
Osteogenic cells	0.175 (0.028)	0.164 (0.047)	0.194	0.254	0.339	0.569	0.809
Spleen	0.303 (0.055)	0.316 (0.063)	0.365	0.571	0.914	1.63	3.93
Thymus	0.193 (0.035)	0.201 (0.053)	0.229	0.335	0.534	0.935	2.22
Thyroid	0.161 (0.029)	0.154 (0.048)	0.190	0.296	0.487	0.878	2.02
Urinary bladder wall	1.67 (0.398)	1.41 (0.396)	1.83	2.96	4.76	8.38	21.9
Uterus/ Testes	0.170 (0.025)	0.322 (0.080)	0.318	0.542	0.785	1.26	2.82
Total body	0.175 (0.027)	0.188 (0.050)	0.203	0.316	0.494	0.882	2.14

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