Fig. 1
Conceptual representation of kinetic models for organs used for TIAC calculations. In the 4-point model (A), TIAC is calculated individually by analytically integrating the mono-exponential fit functions (blue lines) with respective effective half-lives Teff,i between subsequent data points, and assuming linear increase until the first data point. In the 3-point models (B), missing data points are substituted by median Teff,i from patients with available data and used for integration