Table 4 Average total volume of distribution (V_T), and 2TCM fit weighted symmetrical mean absolute percentage error (wsMAPE) for mice anesthetized with isoflurane or ketamine-xylazine

CTX

29.8 \(\pm\) 1.86

30.9 \(\pm\) 1.94

1.16 \(\pm\) 0.33

0.918 \(\pm\) 0.27

10.6 \(\pm\) 1.34

14.0 \(\pm\) 1.81

2.28 \(\pm\) 1.21

1.12 \(\pm\) 0.44

CP

24.7 \(\pm\) 1.90

25.7 \(\pm\) 1.83

1.56 \(\pm\) 0.34

1.23 \(\pm\) 0.28

9.54 \(\pm\) 1.25

12.5 \(\pm\) 1.72

2.53 \(\pm\) 1.28

1.28 \(\pm\) 0.41

TH

34.9 \(\pm\) 2.17

36.3 \(\pm\) 2.35

1.99 \(\pm\) 0.63

1.58 \(\pm\) 0.61

12.9 \(\pm\) 1.84

17.6 \(\pm\) 3.37

3.04 \(\pm\) 1.57

1.78 \(\pm\) 0.53

HC

31.2 \(\pm\) 1.54

32.5 \(\pm\) 1.83

1.47 \(\pm\) 0.34

1.17 \(\pm\) 0.39

12.0 \(\pm\) 1.62

15.7 \(\pm\) 2.15

2.60 \(\pm\) 1.28

1.35 \(\pm\) 0.39

CB

22.1 \(\pm\) 2.15

22.9 \(\pm\) 1.83

1.59 \(\pm\) 0.35

1.32 \(\pm\) 0.29

8.23 \(\pm\) 0.99

10.9 \(\pm\) 1.39

2.63 \(\pm\) 0.91

1.48 \(\pm\) 0.39