Fig. 4

Workflow for the \(h_{PVC}\) and \(h_{AFC}\) methodologies for kernel determination; a simulated GT emission; b GT emission convolved with \(h_{PVC}\) and down-sampled to PET voxel (vx) size; c AC non-TOF reconstructed and post-filtered (\(h_{PF}\) = 6 mm) PET; d simulated GT mu-map; e mu-map convolved with \(h_{AFC}\) and down-sampled to PET vx size; f AFC-AC PET (AC non-TOF reconstructed and post-filtered (\(h_{PF}\) = 6 mm) PET divided by voxel-wise AFs, derived from (e)); g GT emission down-sampled to PET vx size; h GT mu-map down-sampled to PET vx size; i GT AF-corrected PET image. “Minimise RMSE in VOIs” refers to the six VOIs in the lung