Gamma camera-specific reference standards for radioactive iodine uptake measurements

Mourik, Jurgen E. M.; Derks, Mark; te Beek, Erik T.; ten Broek, Marc R. J.

doi:10.1186/s40658-023-00575-2

EJNMMI Physics

Table 1 Results from the survey among Dutch hospitals with a nuclear medicine department

From: Gamma camera-specific reference standards for radioactive iodine uptake measurements

Survey questions	Academic medical center #1	Academic medical center #2	Community hospital #1	Community hospital #2	Community hospital #3	Community hospital #4	Community hospital #5	Community hospital #6
1. Do you perform Iodine-131 therapy (e.g., for treatment of hyperthyroidism, multi-nodular goiter of toxic adenoma)?	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
2. Which radionuclide do you use as reference source?	Iodine-123	Iodine-131	Iodine-123	Iodine-123	Iodine-123	Iodine-123	Iodine-123	Iodine-123
3. What amount of activity (in MBq) do you use for the reference source?	11.1	0.5	11.1	11.1	18.5	37	18.5	11.1
4. Which formulation do you use for the reference source?	Capsule	Capsule	Capsule	Capsule	Capsule	Capsule	Capsule	Capsule
5. Do you use a phantom for measurement of the reference source? If so, what kind of phantom?	Neck phantom with a compartment for a capsule	Neck phantom with a compartment for a standard vial	Neck phantom with a compartment for a standard vial	No phantom	Neck phantom with a compartment for a standard vial	Neck phantom with a compartment for a capsule	Neck phantom with a compartment for a standard vial	Neck phantom with a compartment for a capsule
6. How do you prepare the reference source (before placement in the phantom)?	Direct placement of the capsule inside the phantom	Dissolvement of the capsule in (warm) water in a standard vial	Dissolvement of the capsule in (warm) water in a standard vial	Dissolvement of the capsule in (warm) water in a standard vial	Dissolvement of the capsule in (warm) water in a standard vial	Direct placement of the capsule inside the phantom	Dissolvement of the capsule in (warm) water in a standard vial	Direct placement of the capsule inside the phantom
7. How often is a new reference source prepared?	Daily	Daily	Weekly	Weekly	Prior to each patient	Daily	Weekly	Weekly
8. How often is the reference source measured?	Daily	Prior to each patient	Weekly	Weekly	Prior to each patient	Prior to each patient	Daily	Prior to each patient
9. What distance (in cm) between phantom and collimator head is used?	10	11.5	6.7	10	10	10	12	10
10. How long is the reference source measured?	1 min	2 min	100 kilocounts	5 min	1 min	5 min	10 min	1 min
11. Do you perform a background measurement?	No	Yes, in a separate background scan	No	Yes, in a separate background scan	Yes, in the neck phantom image	No	Yes, in a separate background scan	No
12. What method is used for determining the number of counts of the reference source?	Manual ROI	Total counts in the whole image	Automatic ROI	Square box ROI	Square box ROI	Automatic ROI	Automatic ROI	Automatic ROI
13. What type of equipment do you use for RAIU measurement?	Siemens Symbia T6	Siemens Symbia and Symbia Intevo	Siemens Symbia	Siemens Symbia S or Symbia T	Siemens Symbia and Symbia Intevo	Siemens Symbia T and Symbia Intevo	Siemens Symbia T2	Siemens Symbia T2

Survey questions	Community hospital #7	Community hospital #8	Community hospital #9	Community hospital #10	Community hospital #11	Community hospital #12	Community hospital #13	Community hospital #14	Community hospital #15
1. Do you perform Iodine-131 therapy (e.g., for treatment of hyperthyroidism, multi-nodular goiter of toxic adenoma)?	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
2. Which radionuclide do you use as reference source?	Iodine-131	Iodine-123	Iodine-123	Iodine-131	Iodine-123	Iodine-123	Iodine-123	Iodine-123	Iodine-123
3. What amount of activity (in MBq) do you use for the reference source?	10	18.5	18.5	0.5	3.7	10	11.1	3.7	18.5
4. Which formulation do you use for the reference source?	Syringe	Capsule	Capsule	Capsule	Capsule	Syringe	Capsule	Capsule	Capsule
5. Do you use a phantom for measurement of the reference source? If so, what kind of phantom?	No phantom	No phantom	Neck phantom with a compartment for a standard vial	Neck phantom with a compartment for a standard vial	Neck phantom with a compartment for a standard vial	No phantom	Neck phantom with a compartment for a capsule	No phantom	No phantom
6. How do you prepare the reference source (before placement in the phantom)?	Not applicable	Dissolvement of the capsule in (warm) water in a standard vial	Dissolvement of the capsule in (warm) water in a standard vial	Dissolvement of the capsule in hydrochloric acid	Direct placement of the capsule in a vial inside the phantom	Placement of syringe on shoulder of patient	Direct placement of the capsule inside the phantom	Not applicable	Not applicable
7. How often is a new reference source prepared?	One every two weeks	Daily	Weekly	Daily	Prior to each patient	Prior to each patient	Weekly	Prior to each patient	Daily
8. How often is the reference source measured?	Prior to each patient	Daily	Weekly	Prior to each patient	Prior to each patient	Prior to each patient	Weekly	Prior to each patient	Prior to each patient
9. What distance (in cm) between phantom and collimator head is used?	Similar distance to the patient scan procedure	10	10	25	20	As close to patient as possible	6	Not applicable	13
10. How long is the reference source measured?	1 min	5 min	1 min	5 min	5 min	2 min	1 min	Reference source is scanned together with the patient	1 min
11. Do you perform a background measurement?	Yes, in a separate background scan	No	Yes, in the neck phantom image	Yes, in the patient image	Yes, in a separate background scan	Yes, in the patient image	Yes, in the neck phantom image	Yes, in the patient image	No
12. What method is used for determining the number of counts of the reference source?	Automatic ROI	Automatic ROI	Square box ROI	Probe, Iodine-131 peak (330–418 keV)	Total counts in the whole image	Square box ROI	Automatic ROI	Square box ROI	Automatic ROI
13. What type of equipment do you use for RAIU measurement?	MED Nuklear-Medizintechnik upt2000	Siemens Symbia S	Siemens Symbia S and Symbia Intevo	Canberra Unispec	Siemens Intevo	Siemens Symbia T	GE NM/CT 870 DR	GE 640/670	Siemens Symbian Intevo

Back to article page