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Table 4 Individual tumor and kidney absorbed dose predictions versus observations for [177Lu]Lu-HA-DOTATATE, followed by calculated RPEs per patient (ID2–ID10)

From: Predicting [177Lu]Lu-HA-DOTATATE kidney and tumor accumulation based on [68Ga]Ga-HA-DOTATATE diagnostic imaging using semi-physiological population pharmacokinetic modeling

Absorbed dose (Gy)

ID2

ID3

ID4

ID5

ID6

ID7

ID8

ID9

ID10

Tumor

 Observed

24.4

14.4

29.3

38.3

8.67

34.4

19.5

12.4

27.7

 Predicted

21.3

17.4

19.6

18.7

5.62

25.5

28.1

12.1

21.5

 RPE

−13%

21%

−33%

−51%

−35%

−26%

44%

−3%

−23%

Kidney

 Observed

–

3.12

2.21

1.19

5.38

3.92

3.79

4.41

3.71

 Predicted

–

2.57

2.57

2.69

2.17

2.26

2.81

2.51

2.75

 RPE

–

33%

−18%

21%

82%

−58%

−28%

−34%

−38%

  1. RPE, relative prediction error (((predicted – observed)/observed) * 100%)