EJNMMI Physics

Table 3 Individual tumor and kidney AUC predictions versus observations for [¹⁷⁷Lu]Lu-HA-DOTATATE, followed by calculated RPEs per patient (ID2–ID10)

From: Predicting [¹⁷⁷Lu]Lu-HA-DOTATATE kidney and tumor accumulation based on [⁶⁸Ga]Ga-HA-DOTATATE diagnostic imaging using semi-physiological population pharmacokinetic modeling

AUC_0-tlast (mg*h/L)	ID2	ID3	ID4	ID5	ID6	ID7	ID8	ID9	ID10
Tumor
Observed	3.32	2.09	5.29	4.69	1.38	2.80	2.94	1.76	2.59
Predicted	2.95	2.67	4.05	2.89	0.825	3.06	3.16	1.50	2.60
RPE	−11%	28%	−23%	−38%	−40%	9%	8%	−14%	0%
Kidney
Observed	–	0.520	0.634	0.334	0.902	0.564	0.443	0.764	0.621
Predicted	–	0.533	0.680	0.469	0.408	0.479	0.410	0.496	0.426
RPE	–	4%	14%	41%	−53%	−12%	−10%	−32%	−32%

AUC_0-tlast, area under the curve, calculated from time is 0 to time of the last measurement; RPE, relative prediction error (((predicted – observed)/observed) * 100%)

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