Table 2 Overview of final model parameter differences for [⁶⁸Ga]Ga-HA-DOTATATE and [¹⁷⁷Lu]Lu-HA-DOTATATE, where compartments represent blood (1), spleen (2), kidney (3), tumor (4), a SSTR-expressing (5) and rest (6) compartment

Structural parameters

 k₁₀ (h⁻¹)

0.25

0.575

 k₁₂ (h⁻¹)

0.21

0.0607 (0.29-fold difference (15%))

 k₂₀ (h⁻¹)

0.01

0.01

 k₁₃ (h⁻¹)

0.22

0.107 (0.49-fold difference (15%))

 k₃₀ (h⁻¹)

0.01

0.01

 k₁₄ (h⁻¹)

0.11

0.157 (1.43-fold difference (14%))

 k₄₀ (h⁻¹)

0.01

0.00375 (0.38-fold difference (35%))

 k₁₅ (h⁻¹)

2.5

2.5

 k₅₀ (h⁻¹)

0.01

0.01

 k₁₆ (h⁻¹)

1

1

 k₆₀ (h⁻¹)

0.01

0.01

 V1 (L)

4

4

 V2 (L)

0.21

0.21

 V3 (L)

0.3

0.3

 V5 (L)

4

4

 V6 (L)

50

50

 Fraction unbound in plasma

0.69

0.57

 B_MAX compartment 2 (nmol/L)

16.7

16.7

 B_MAX compartment 3 (nmol/L)

6.7

6.7

 B_MAX compartment 4 (nmol/L)

30

30

 B_MAX compartment 5 (nmol/L)

2.4

2.4

IIV (CV%)

 k₁₀

31.6%

31.6%

 k₁₂ or BMAX compartment 2**

50%

50%

k₁₃ or BMAX compartment 3**

50%

50%

 k₁₄ or BMAX compartment 4**

50%

50%

 k₁₅ or BMAX compartment 5**

31.6%

31.6%

Structural effect

 Tumor volume on k₁₄

1

0.67 (17%)

RUV

 Proportional error (CV%)

31.6%

31.6%