Table 1 Intracellular self-dose S-values (GyBq−1 s−1) for nuclides in the 225Ac decay chain from different source distributions targeting the nucleus
From: A GATE simulation study for dosimetry in cancer cell and micrometastasis from the 225Ac decay chain
Nuclide | S-value (GyBq−1 s−1) | |||
|---|---|---|---|---|
Cell surface | Cytoplasm | Nucleus | Whole Cell | |
225Ac | 4.84 × 10–2 (− 4.4%) | 6.29 × 10–2 (− 5.9%) | 1.40 × 10–1 (− 4.5%) | 1.02 × 10–1 (− 5.1%) |
221Fr | 4.36 × 10–2 (− 7.3%) | 5.87 × 10–2 (− 5.7%) | 1.30 × 10–1 (− 4.8%) | 9.64 × 10–2 (− 3.6%) |
217At | 4.09 × 10–2 (− 4.9%) | 5.42 × 10–2 (− 4.8%) | 1.18 × 10–1 (− 5.5%) | 8.73 × 10–2 (− 4.8%) |
213Bi | 1.22 × 10–3 (− 3.6%) | 1.49 × 10–3 (− 12.2%) | 3.62 × 10–3 (− 6.4%) | 2.64 × 10–3 (− 6.0%) |
213Po | 3.31 × 10–2 (− 12.1%) | 4.48 × 10–2 (− 10.1%) | 1.04 × 10–1 (− 5.6%) | 7.62 × 10–2 (− 5.5%) |
209Tl | 1.91 × 10–4 (− 48.8%) | 2.48 × 10–4 (− 56.2%) | 5.62 × 10–4 (− 70.9%) | 4.13 × 10–4 (− 67.3%) |
209Pb | 2.70 × 10–4 (8.5%) | 3.69 × 10–4 (8.8%) | 8.51 × 10–4 (8.1%) | 6.17 × 10–4 (8.6%) |
Total | 1.67 × 10–1 (− 6.9%) | 2.21 × 10–1 (− 6.5%) | 4.94 × 10–1 (− 5.0%) | 3.64 × 10–1 (− 4.7%) |