Accurate molecular imaging of small animals taking into account animal models, handling, anaesthesia, quality control and imaging system performance

EJNMMI Physics

Table 3 Maximal volumes of blood sampling

Species	Body weight	Blood volume per kilogramme body weight	Blood volume at typical body weight	Maximal volume for blood sampling
Human	70 kg	67 mL/kg	4.7 L
Rat	400 g	64 mL/kg	26 mL	2.6 mL (10 %) at once
				0.26 mL (1 %)/24 h repeatedly
				6.5 mL (25 %) within 28 days
Mouse	25 g	59 mL/kg	1.5 mL	0.15 mL (10 %) at once
				0.015 mL (1 %)/24 h repeatedly
				0.37 mL (25 %) within 28 days