Metal artifact reduction in patients with dental implants using multispectral three-dimensional data acquisition for hybrid PET/MRI
© Gunzinger et al; licensee Springer. 2014
Received: 19 August 2014
Accepted: 6 November 2014
Published: 20 December 2014
Hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) shows high potential for patients with oropharyngeal cancer. Dental implants can cause substantial artifacts in the oral cavity impairing diagnostic accuracy. Therefore, we evaluated new MRI sequences with multi-acquisition variable-resonance image combination (MAVRIC SL) in comparison to conventional high-bandwidth techniques and in a second step showed the effect of artifact size on MRI-based attenuation correction (AC) with a simulation study.
Twenty-five patients with dental implants prospectively underwent a trimodality PET/CT/MRI examination after informed consent was obtained under the approval of the local ethics committee. A conventional 3D gradient-echo sequence (LAVA-Flex) commonly used for MRI-based AC of PET (acquisition time of 14 s), a T1w fast spin-echo sequence with high bandwidth (acquisition time of 3.2 min), as well as MAVRIC SL sequence without and with increased phase acceleration (MAVRIC, acquisition time of 6 min; MAVRIC-fast, acquisition time of 3.5 min) were applied. The absolute and relative reduction of the signal void artifact was calculated for each implant and tested for statistical significance using the Wilcoxon signed-rank test. The effect of artifact size on PET AC was simulated in one case with a large tumor in the oral cavity. The relative difference of the maximum standardized uptake value (SUVmax) in the tumor was calculated for increasing artifact sizes centered over the second molar.
The absolute reduction of signal void from LAVA-Flex sequences to the T1-weighted fast spin-echo (FSE) sequences was 416 mm2 (range 4 to 2,010 mm2) to MAVRIC 481 mm2 (range 12 to 2,288 mm2) and to MAVRIC-fast 486 mm2 (range 39 to 2,209 mm2). The relative reduction in signal void was significantly improved for both MAVRIC and MAVRIC-fast compared to T1 FSE (−75%/− 78% vs. − 62%, p < 0.001 for both). The relative error for SUVmax was negligible for artifacts of 0.5-cm diameter (−0.1%), but substantial for artifacts of 5.2-cm diameter (−33%).
MAVRIC-fast could become useful for artifact reduction in PET/MR for patients with dental implants. This might improve diagnostic accuracy especially for patients with tumors in the oropharynx and substantially improve accuracy of PET quantification.
KeywordsMAVRIC Attenuation correction Signal voids Image noise
In head and neck tumor staging, computed tomography (CT) and magnetic resonance imaging (MRI) play an important role in the evaluation of local tumor extension, since clinical and endoscopic examination often results in underestimation of disease, as deep infiltration of the surrounding tissues can be hard to detect -. Generally, diagnostic imaging is performed after clinical and endoscopic examination for staging and therapy planning and as a base for further follow-up examinations . Functional imaging like fluorodeoxyglucose (FDG) positron emission tomography (PET) measures the metabolic activity and is superior in nodal staging compared to CT or MRI ,. For accurate anatomic localization and spatial resolution, cross-sectional hybrid imaging methods like PET/CT are superior than PET alone ,. For oropharyngeal cancer, T-staging could be optimized with PET/MRI compared to PET/CT, due to a higher soft tissue contrast ,. This raises the interest to improve PET/MRI protocols for specific indications taking into account organ and pathology dependent adaptations ,. PET/MRI has already been shown to be feasible for imaging head and neck cancer with a whole-body PET/MRI system without impairment of PET quality .
The two main problems for MRI of the oral cavity are patient motion and artifacts of dental alloys due to magnetic susceptibility artifacts . To reduce patient motion, a short acquisition time is favorable and the patient should be well instructed and have a comfortable position . The extent of artifacts from dental alloys depends on the composition, with ferromagnetic material causing strongest artifacts . However, even titanium alloys generally considered ‘MRI-compatible’ may lead to significant susceptibility artifacts due to their paramagnetic properties . Different MRI sequences are differently prone to those susceptibility artifacts depending on the spin excitation technique, data acquisition strategy, and receiver bandwidth -. Artifacts might appear as signal voids, hyperintense signals caused by signal pile-up due to distortion of spatial encoding, or geometric distortions ,,. An optimized MRI sequence design can reduce these artifacts significantly  and thereby improve diagnostic accuracy and also reduce artifacts for MR-based attenuation correction (AC), since large signal voids can lead to substantial underestimation of FDG uptake within the area of the artifact when MRI-based AC is performed .
Conventional strategies to optimize the image quality close to metal implants are a high bandwidth per voxel, 3D spatial encoding, a high-resolution matrix, and a multiecho spin-echo (SE) sequence or turbo/fast SE sequence .
The relatively new multi-acquisition variable-resonance image combination (MAVRIC) as well as the slice encoding for metal artifact correction (SEMAC) technique has shown very promising results in reducing susceptibility artifacts in arthroplasty imaging -. MAVRIC images can be used in extreme off-resonance conditions by splitting very large spectral distributions into independently imaged frequency bins with a multispectral three-dimensional technique-space composition . SEMAC uses a slice selection gradient for excitation and a view-angle tilting (VAT) compensation gradient for readout . MAVRIC and SEMAC showed significantly smaller artifact extent compared to fast spin-echo (FSE) imaging .
Given the good results of MAVRIC in arthroplasty imaging, we investigated this technique for its capability to depict the oral cavity in the presence of metallic dental implants by comparing artifacts in MRI datasets acquired with FSE, standard MAVRIC SL, and a MAVRIC-fast with an increased phase acceleration allowing a shorter repetition time (TR), resulting in notably shorter acquisition time. Furthermore, a simulation study was performed to calculate the effect of different artifact sizes on maximum standardized uptake value SUVmax in PET images after MRI-based AC.
This prospective study was conducted with patients referred for FDG PET/CT who gave written informed consent for additional MRI scans during the FDG uptake time. Patients were included if they had dental implants and did not have any contraindication for MRI. Between September 2013 and January 2014, 25 patients (19 males and 6 females) were included. The study was carried out with the approval of the local ethics committee. Examinations were performed using a sequential trimodality PET/CT-MRI system consisting of a GE Healthcare Discovery 750w 3T MRI and a GE Healthcare Discovery 690 PET/CT (GE Healthcare, Milwaukee, WI, USA) . A shuttle device enabling to transfer the patient from the MRI to the PET/CT without changing the patient's position was used. Standard PET/CT was acquired and axial images of the oral cavity were obtained from CT (120 kV, tube current with automated dose modulation with 60 to 440 mA/slice).
The in-phase images of a dual-echo gradient-echo pulse sequence (LAVA-Flex (GE Healthcare, Milwaukee, WI, USA) with TR 4.3 ms, echo time (TE) 1.3 ms, a matrix size of 288 × 224 with a spatial resolution of 1.7 × 2.2 × 4.0 mm; covering a field of view of 50 cm, using a bandwidth of 142.86 kHz, with an acceleration factor of 2 and a total acquisition time of 14 s) commonly used in whole-body MR imaging for AC of PET images were used as a reference ,. A 2D encoded T1-weighted FSE sequence with increased bandwidth (TR 339 ms, TE 13.6 ms, slice thickness 3 mm, receiver bandwidth 142.86 kHz, acceleration factor of 1.75, acquisition time of 3.16 min) was acquired in axial orientation. Additionally, two MAVRIC sequences were applied, with 24 spectral bins of 2.25 kHz each to cover ±11 kHz (MAVRIC SL, GE Healthcare, Milwaukee, WI, USA). The standard MAVRIC SL with a phase acceleration of 2 resulted in a TR of 4,000 ms and a TE of 7.6 ms (acquisition time of 6 min). To reduce scan time, the phase acceleration was increased to 3 for MAVRIC-fast allowing a shorter TR of 3,000 ms (TE 7.6 ms), resulting in an acquisition time of 3.5 min. All three tested sequences had identical matrix sizes of 384 × 256 with an in-plane spatial resolution of 0.9 mm.
The signal void was quantitatively assessed for every implant using a commercially available viewing workstation (GE Advantage Windows 4.4). On the axial images of all four sequences, the largest diameter a 1 and the corresponding orthogonal diameter a 2 were measured by a board-certified radiologist [IAB]. The area of the artifact was calculated by assuming the shape of the artifact to be elliptical using the equation A = π × (a 1/2) × (a 2/2), with A meaning the area of the ellipse.
The qualitative image analysis was performed by two board-certified radiologists [IAB, PVH]. Both compared the four sequences independently and assessed the delineation of anatomical details of the oral cavity on a five-point scale with 1 = good depiction of anatomical structures, 2 = structures visible with slight blurring, 3 = oral cavity visible with substantial blurring, 4 = oral cavity only partially visible, and 5 = oral cavity not assessable. Furthermore, the image quality was assessed for spatial blurring and image noise on a five-point scale: 1 = no artifacts, 2 = barely visible artifacts, 3 = visible artifacts without diagnostic impairment, 4 = diagnostic impairment, and 5 = severe artifacts, non-diagnostic . Hyperintense ringing artifacts around dental alloys were noted separately.
Based on the assessment of spatial blurring on LAVA-Flex sequences, two groups were generated: group 1 with low to moderate artifacts (categories 1 to 3) and group 2 with blurring artifacts impairing diagnosis (categories 4 and 5). Differences in qualitative data (anatomic distinction, blurring, or image noise) were compared for T1-FSE and MAVRIC-fast between both groups.
MRI-based PET AC
To estimate the effect of artifact size on PET quantification if MRI sequences are used for AC, we performed a simulation analysis for one patient with a large carcinoma in the right tonsil. Therefore, artifacts of various sizes were artificially inserted into the AC atlas routinely used for the PET/MR reconstruction. The simulated artifacts were created by inserting a spherical volume into the image and setting the signal to 0 within the volume. The artifacts were all centered over the second molar in the right maxilla and spherical in shape with increasing diameters from 0.5 to 5 cm. The difference between the baseline image, without artifact, and each reconstructed image with an artificial artifact was calculated. The normalized difference between the baseline PET and artifact-corrected PET was used to produce a contour map showing the percentage difference from baseline in each area of the image.
Statistic evaluation was performed with statistical software (SPSS Statistics 22.0, Chicago, IL, USA). The LAVA-Flex sequence was used as a reference. Differences in signal void areas were assessed with the Wilcoxon signed-rank test (Kolmogorov-Smirnov test: p < 0.05). Absolute and relative reduction of artifact sizes were calculated for T1-FSE, MAVRIC SL, and MAVRIC-fast sequences and compared using the Wilcoxon signed-rank test. Differences in scores for the qualitative data (anatomic distinction, blurring, or image noise) were compared using the Wilcoxon signed-rank test. Significance level was set at a p value of <0.05. Agreement between the two readers was determined using Cohen's kappa, with κ values of 0 indicating poor agreement, 0.01 to 0.2 slight agreement, 0.21 to 0.40 fair agreement, 0.41 to 0.60 moderate agreement, 0.61 to 0.80 good agreement, and 0.81 to 1 excellent agreement . Isocontour maps showing the percentage difference between PET scans after AC with baseline MR images and MR images with increasing artifact size were calculated using MATLAB Software version 2013b (MathWorks Inc., Natick, MA, USA).
A total of 46 dental implants could be identified in the 25 patients with an average age of 60 years (range 28 to 76 years) and average weight of 74 kg (range 44 to 109 kg). Image quality and acquisition were acceptable for all patients.
Overview of artifact sizes in axial slides from dental alloys in the applied sequences
Size of artifact (mm2)
Absolute reduction of artifact (mm2), compared to LAVA-Flex
Relative reduction of artifact (%), compared to LAVA-Flex
The relative artifact reduction with T1-FSE showed a mean of −62%. Both MAVRIC SL and MAVRIC-fast improved the artifact reduction compared to T1-FSE with a mean of −75% (p < 0.001) and −78% (p < 0.001), respectively (Table 1, Figure 1b). MAVRIC-fast improved relative artifact reduction compared to MAVRIC SL significantly (p = 0.017).
Overview of qualitative image analysis and inter-observer agreement
Kappa ( κ )
Distinction of anatomy
3.8 ± 0.7
3.6 ± 0.8
4.0 ± 0.7
4.0 ± 0.7
3.8 ± 0.5
3.7 ± 0.6
Distinction of anatomy
1.8 ± 0.8
2.1 ± 0.8
2.6 ± 0.7
2.8 ± 0.8
1.6 ± 0.8
1.5 ± 0.8
Distinction of anatomy
1.9 ± 0.6
1.8 ± 0.6
1.4 ± 0.6
1.4 ± 0.6
2.1 ± 0.5
2.0 ± 0.4
Distinction of anatomy
1.8 ± 0.4
1.6 ± 0.5
1.4 ± 0.6
1.4 ± 0.6
2.2 ± 0.5
2.4 ± 0.6
There was an increase in image noise for MAVRIC-fast compared to MAVRIC SL for both readers, reaching statistical significance for reader 2 (p = 0.011). For anatomical distinction or spatial blurring, there was no relevant difference between MAVRIC SL and MAVRIC-fast.
Regarding spatial blurring, T1-FSE had substantially more artifacts with a mean of 2.64 (±0.76) and 2.84 (±0.80) than MAVRIC SL (mean 1.36 (±0.64) and 1.44 (±0.65), p < 0.001) or MAVRIC-fast (mean 1.36 (±0.63) and 1.40 (±0.65), p < 0.001). Anatomical distinction was overall slightly better for MAVRIC-fast compared to T1-FSE. However, both readers rated image noise significantly better for T1-FSE compared to MAVRIC SL and MAVRIC-fast (p < 0.001).
For anatomical distinction, a moderate to excellent inter-observer agreement was noted (κ = 0.58 to 0.85). For image quality, inter-observer agreement is good to excellent regarding blurring (κ = 0.69 to 0.93) and moderate to excellent for image noise (κ = 0.54 to 0.89) (Table 2).
Image quality of T1-FSE and MAVRIC-fast depending on LAVA-Flex assessment concerning blurring
Distinction of anatomy
1.00 ± 0.00
1.80 ± 0.45
1.25 ± 0.50
1.50 ± 0.58
2.05 ± 0.76
1.75 ± 0.44
2.29 ± 0.72
1.67 ± 0.48
2.00 ± 0.71
1.20 ± 0.45
2.00 ± 0.82
1.00 ± 0.00
2.80 ± 0.70
1.40 ± 0.68
3.00 ± 0.71
1.48 ± 0.68
1.00 ± 0.00
2.00 ± 0.71
1.00 ± 0.00
2.00 ± 0.82
1.70 ± 0.87
2.30 ± 0.47
1.62 ± 0.81
2.43 ± 0.51
Effect of MRI-based PET AC
Change of SUV max within the tumor with increasing sizes of the artificial artifact
Artifact diameter (cm)
SUV max (g/ml)
Difference in SUV max (%)
With this study, we can confirm that MAVRIC is also capable of reducing artifacts from dental implants within the oral cavity. Taking LAVA-Flex images as a reference, the reduction of the artifact size in the axial plane was around −75% for MAVRIC SL (and −78% for MAVRIC-fast). This is also a significant improvement compared to the artifact reduction accomplished by a T1-FSE sequence with large bandwidth (−62%). There was a very broad range of signal void sizes for all sequences, due to the various sizes and compositions of the dental alloys . For patients with moderate artifacts in LAVA-Flex (group 1, grades 1 to 3), T1-FSE yielded good image quality with small artifacts due to dental alloys. For patients with extensive blurring due to dental alloys in LAVA-Flex (group 2, grades 4 and 5), spatial blurring in T1-FSE was significantly higher compared to MAVRIC-fast (p < 0.001 for both readers) (Table 3).
MAVRIC-fast was optimized to reduce the acquisition time of the conventional MAVRIC SL sequence protocol for potential integration into a whole-body PET/MRI protocol. By increasing the phase acceleration from 2 to 3, the echo train length (ETL) was reduced. As susceptibility artifacts increase with echo time , this time optimization step also resulted in a further reduction of the size of signal voids. On the other hand, the signal-to-noise ratio decreases with phase acceleration leading to an overall higher image noise for MAVRIC-fast compared to MAVRIC (Table 2). An increase of phase acceleration of MAVRIC, therefore, might only be feasible in areas with a sufficient signal-to-noise ratio obtained by a dedicated receiver coil. In the oral cavity, blurring by dental alloys was approximately equal for MAVRIC SL and MAVRIC-fast, but the MAVRIC-fast technique with TR of 3,000 ms resulted in an acquisition time of 3.5 min, compared to 6 min for MAVRIC SL. This gives a reasonable scan time for clinical use, comparable with that of the T1-FSE sequence of 3.2 min. Overall, MAVRIC-fast has shown similar imaging results as MAVRIC SL within a favorable acquisition time.
In addition to a potential improvement of CT-based AC , MRI also increases the soft tissue contrast of the oral cavity. This is especially beneficial in FDG PET, since muscle activity can lead to variable FDG uptake in the floor of the mouth . To differentiate this physiological FDG activity from malignancy, it is important that the MRI sequence allows a good anatomical depiction of the oral cavity . T1-FSE images showed better spatial resolution than MAVRIC images in earlier publications . This was also true for the oral cavity in our study with less noise for T1-FSE compared to MAVRIC SL and MAVRIC-fast for most cases. On the other hand, there was a significantly better reduction of spatial blurring for MAVRIC-fast compared to T1-FSE in patients with large artifacts on LAVA Flex (group 2, Table 3). Regarding image fusion, artifact size did not affect the coregistration between MRI and PET in our trimodality setup, since hardware-based coregistration is independent of image information and visual corrections, which if necessary are performed using bony structures, not affected by focal signal voids.
One limitation of this study is that we could not investigate the alloy composition of the dental implants and had no information of their exact material. Therefore, the influence of different materials on the artifacts in the applied sequences could not be addressed. However, this is the most realistic clinical situation, as patients usually are not aware of the exact composition of their dental implants. A further limitation is a certain uncertainty for measurements that might lead to a slight variability in measured sizes of signal voids and that we only compared vendor-specific sequences and could not investigate SEMAC or compare MAVRIC with SEMAC. Also, volume-selective 3D multispectral imaging (VS-3D-MSI), a fusion of SEMAC and MAVRIC technique, has been reported to provide excellent artifact suppression. In dental imaging, SEMAC reduced artifacts from dental alloys composed of high-susceptibility materials of more than 50% compared to conventional SE sequences . It might be valuable to have a direct comparison of these two sequences, which have proven their capability of artifact reduction. With the current study, we could not implement MAVRIC-fast for direct AC correction and therefore could not quantify the direct effect on SUV values. With the additional simulation study, we however could show the potential impact of different artifact sizes on SUV values in a real tumor. Future studies with integration of MAVRIC-fast information into the AC map will be needed to further analyze this aspect.
In summary, this is the first study showing that MAVRIC-fast could be integrated into whole-body PET/MRI imaging for patients with large signal voids due to dental alloys. MAVRIC SL reduced artifact size and increased precise anatomic delineation of the oral cavity. This reduction should improve the accuracy of PET quantification - since large signal voids lead to substantial SUV underestimation. With MAVRIC-fast, acquisition time was kept reasonably short, slightly worsening image noise but further reducing artifact size compared to T1-FSE or MAVRIC SL. Therefore, MAVRIC-fast could be integrated into the diagnostic imaging work-up for head and neck cancer evaluation in patients with dental alloys and potentially also improve AC.
The authors thank the technologists and the administrative staff at the University Hospital of Zurich and the Universi for their help in acquiring the data and freeing up resources.
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