Volume 2 Supplement 1

Proceedings of the 4th PSMR Conference on PET/MR and SPECT/MR

Open Access

PET/MR: improvement of the UTE μ-maps using modified MLAA

  • Didier Benoit1,
  • Claes Ladefoged2,
  • Ahmadreza Rezaei3,
  • Sune Keller1,
  • Flemming Andersen1,
  • Liselotte Hojgaard1,
  • Adam Espe Hansen2,
  • Soren Holm1 and
  • Johan Nuyts3
EJNMMI Physics20152(Suppl 1):A58

DOI: 10.1186/2197-7364-2-S1-A58

Published: 18 May 2015

For a quantitative analysis in positron emission tomography (PET) or single-photon emission computed tomography (SPECT), attenuation correction (AC) is mandatory. CTscans or transmission scans are common tools for determination of the attenuation μ-map, but in the case of a PET/MR hybrid system it is difficult to associate one of these scans. Many techniques have been developed in order to improve AC for PET/MR. Some methods are based on template- or atlas techniques, other methods apply a segmentation technique based on Dixon or UTE (Ultrashort Echo Time) MR to create the μ-map, followed by a standard OSEM reconstruction (OSEM/DIXON and OSEM/UTE). A different approach for AC has been developed by employing the emission sinogram data in the μ-map derivation. In this context, we modified the iterative MLAA (Maximum-Likelihood reconstruction of Attenuation and Activity) algorithm to improve the resulting emission image from the PET/MR system. We constrained the attenuation map update using the UTE μ-map and the T1-weighted (T1w) MR image in order to improve convergence towards a solution. Results show that the modified MLAA algorithm improved the estimated emission image compared to standard OSEM/UTE and OSEM/DIXON. In certain regions of the brain, in particular close to the skull and the air cavities, the modified MLAA algorithm generated less error than OSEM/UTE and OSEM/Dixon. The modified MLAA algorithm is able to compute an attenuation μ-map that is slightly more similar to the aligned CT μ-map than the UTE μ-map.

Authors’ Affiliations

(1)
Rigshospitalet, University of Copenhagen
(2)
Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet Copenhagen
(3)
University of Leuven

Copyright

© Benoit et al; licensee Springer. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.