Volume 2 Supplement 1

Proceedings of the 4th PSMR Conference on PET/MR and SPECT/MR

Open Access

Establishment of an open database of realistic simulated data for evaluation of partial volume correction techniques in brain PET/MR

  • Ana Mota1, 2,
  • Vesna Cuplov1,
  • Jonathan Schott2,
  • Brian Hutton2,
  • Kris Thielemans2,
  • Ivana Drobnjak3,
  • John Dickson2,
  • Julien Bert4,
  • Ninon Burgos3,
  • Jorge Cardoso3,
  • Marc Modat3,
  • Sebastien Ourselin3 and
  • Kjell Erlandsson2
EJNMMI Physics20152(Suppl 1):A44

DOI: 10.1186/2197-7364-2-S1-A44

Published: 18 May 2015

The Erratum to this article has been published in EJNMMI Physics 2015 2:30

The Partial Volume (PV) effect in Positron Emission Tomography (PET) imaging leads to loss in quantification accuracy, which manifests in PV effects (small objects occupy partially the sensitive volume of the imaging instrument, resulting in blurred images). Simultaneous acquisition of PET and Magnetic Resonance Imaging (MRI) produces concurrent metabolic and anatomical information. The latter has proved to be very helpful for the correction of PV effects. Currently, there are several techniques used for PV correction. They can be applied directly during the reconstruction process or as a post-processing step after image reconstruction. In order to evaluate the efficacy of the different PV correction techniques in brain- PET, we are constructing a database of simulated data. Here we present the framework and steps involved in constructing this database. Static 18F-FDG epilepsy and 18F-Florbetapir amyloid dementia PET/MR were selected because of their very different characteristics. The methodology followed was based on four main steps: Image pre-processing, Ground Truth (GT) generation, MRI and PET data simulation and reconstruction. All steps used Open Source software and can therefore be repeated at any centre. The framework as well as the database will be freely accessible. Tools used included GIF, FSL, POSSUM, GATE and STIR. The final data obtained after simulation, involving raw or reconstructed PET data together with corresponding MRI datasets, were close to the original patient data. Besides, there is the advantage that data can be compared with the GT. We indicate several parameters that can be improved and optimized.


Authors’ Affiliations

Instituto de Biofísica e Engenharia Biomédica, FC-UL
Institute of Nuclear Medicine, UCL
Centre of Medical Image Computing, UCL
INSERM UMR1101, LaTIM, CHRU de Brest


© Mota et al; licensee Springer. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.