Volume 1 Supplement 1

Proceedings of the 3rd PSMR Conference on PET/MR and SPECT/MR

Open Access

PET motion correction using PRESTO with ITK motion estimation

  • Melissa Botelho1,
  • Liliana Caldeira2,
  • Juergen Scheins2,
  • Nuno Matela1,
  • Elena Rota Kops2 and
  • N Jon Shah2
EJNMMI Physics20141(Suppl 1):A59

DOI: 10.1186/2197-7364-1-S1-A59

Published: 29 July 2014

The Siemens BrainPET scanner is a hybrid MRI/PET system. PET images are prone to motion artefacts which degrade the image quality. Therefore, motion correction is essential. The library PRESTO converts motion-corrected LORs into highly accurate generic projection data [1], providing high-resolution PET images. ITK is an open-source software used for registering multidimensional data [2]. ITK provides motion estimation necessary to PRESTO.

For this study the Utah phantom, a brain phantom and clinical images were used. The data was simulated with different statistics and included scatter and random events. The data was reconstructed using OP-OSEM [3] with 41 iterations. The patient was administrated with [18]F-FDG. The acquisition took about 35min (96min p.i.). Different motions considering translations and rotations with dimensions of 1, 5, 10 and 30mm and degrees in three axes were simulated with PRESTO. In addition to PET images, EPI sequence [3] images were also used. The metric used in ITK registration algorithm was the Mutual Information. Given a fixed image and a moved image, the outputs are six parameters, which represent motion: three translations and three rotations. Then, the images were corrected in PRESTO using these parameters.

For low statistics (1E6) and larger motion (30mm/degrees) ITK showed considerable errors (Figure 1). PRESTO using ITK estimated parameters can correct well the moved images. Regarding the PET images, clinical data has bigger errors than phantom data as expected. For MR images ITK errors are smaller than for PET images (Figure 1).
Figure 1

Simulated images in the study with Utah phantom (with a hot and a cold cylinder). On left side of the figure, in the first row, are the acquired PET images of the phantom: first transversal view and then coronal view. The next row shows the simulated images with a translational motion of 5mm (in 3axis) and 5 degree of rotation. The last row corresponds to the corrected images using PRESTO. On the right side of the figure are the graphs representing the absolute errors of ITK values. The graphs represent translation and rotation along the x-axis. The other two axes are not represented here but they have the same behavior as the x-axis.

ITK has some limitations, such as, images with low statistics hamper the correction because of the blurring and if the motion is severe the object of study goes out the FOV and then correction is not possible. ITK is a viable image-based correction, which used with PRESTO makes it possible to easily use PET or MR images for motion correction.

Authors’ Affiliations

Institute of Biophysics and Biomedical Engineering, Science Faculty of University of Lisbon
Institute of Neuroscience and Medicine (INM-4), Forschungszentrum Jülich


  1. Scheins J, Ullisch M, Tellmann L, Weirich C, Rota Kops E, Herzog H, Shah NJ: MR-guided PET motion correction in LOR space using generic projection data for image reconstruction with PRESTO. Nuclear Instruments and Methods in Physics Research A 2013, 702: 64–66. 10.1016/j.nima.2012.08.004View ArticleGoogle Scholar
  2. Johnson HJ, McCormick M, Ibáñez L: The ITK Software Guide. Third edition. 2013.Google Scholar
  3. Ullisch MG, Scheins J, Weirich C, Rota Kops E, Celik A, Tellmann L, Stöcker T, Herzog H, Shah NJ: MR-Based PET Motion Correction Procedure for Simultaneous MR-PET Neuroimaging of Human Brain. PLOS ONE 2012,7(11):e48149. 10.1371/journal.pone.0048149PubMed CentralPubMedView ArticleGoogle Scholar


© Botelho et al; licensee Springer 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.